![]() The best inhibition percentage of celery stems water infusion was 90,25%, while the celery leaves water infusion was 69.07% both of at 20% concentration. The result showed the celery stems water infusion extract had better inhibition activity than celery leaves water infusion extract. Infused extract which has the smallest absorption at 290 nm showed a better inhibitory ability of the xanthine oxidase enzyme because the change of xanthine substrate to uric acid is inhibited. ![]() Absorption at 290 nm indicates the presence of a uric acid product from xanthine oxidation by the xanthine oxidase enzyme. The activity of xanthine oxidase enzyme was determined by UV spectrophotometry method and using xanthine substrate. Xanthine oxidase enzyme plays a role in change of hypoxanthine to xanthine and then becomes uric acid. The purpose of this study was to determine the activity of water infusion extract from celery stems and leaves to inhibited xanthine oxidase enzyme. The high prevalence of hyperuresemia in the world, especially in Indonesia makes the research of antihyperurisemia drugs very needed today. ![]() Hyperuricemia is a metabolic disorder because of excessive uric acid production.
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